李高伟 博士 讲师
地址:睢阳校区2号楼302
教育经历
2014.8 -2017.6,南京大学,药学,理学博士(导师:谭仁祥教授/雷新响教授)
2006.9-2009.6,郑州大学,有机化学,理学硕士(导师:王敏灿教授)
2002.9-2006.6,澳门游戏网站平台大全游戏网,化学,理学学士
工作经历
2021.3 -2021.7,合肥工业大学,吴宗铨教授课题组,访问学者
2014.1-至今,澳门游戏网站平台大全游戏网,讲师
2009.9-2014.1,澳门游戏网站平台大全游戏网化学系,助教
主讲课程
有机化学,天然药物化学,药学综合实验,有机化学实验。
研究方向
核磁共振技术有机分析方法,自组装各向异性介质开发,聚合物“活性”/可控合成。
https://orcid.org/0000-0003-1510-6804
主持科研项目
[1] 噻吩嵌段聚合物手性定向介质的合成及其核磁手性分析应用研究(编号21804086),国家自然科学基金,2019.1-2021.12
[2] 炎症小体特异性小分子抑制剂的设计、合成与活性研究(编号192102310143),河南省科技攻关计划项目,2019.1-2020.12
[3] 系列α-取代-γ-丁(烯)内酯的合成新工艺研究(编号13B150189),河南省教育厅,2013.1-2014.12
[4] 抗心律失常药CVT-510关键中间体的合成新工艺和新方法研究(编号2011B150029),河南省教育厅,2011.1-2013.12
代表性研究成果(2015年以来)
1. 论著
[1] Gao-Wei Li, Xiao-Juan Wang*, Dan-Dan Cui, Yu-Fei Zhang, Rong-Yao Xu, Shuai-Hua Shi, Lan-Tao Liu*, Min-Can Wang, Hong-Min Liu, Xin-Xiang Lei*. Azaheterocyclic diphenylmethanol chiral solvating agents for the NMR chiral discrimination of alphasubstituted carboxylic acids. RSC Advances, 2020, 10: 34605-34611.
[2] Gaowei Li, Minshan Ma, Guifang Wang, Xiaojuan Wang, Xinxiang Lei*, Efficient enantiodifferentiation of carboxylic acids using BINOL-based amino alcohol as a chiral NMR solvating agent, Front. Chem., 2020, 8: 336.
[3] Gao-Wei Li, Han Liu, Feng Qiu, Xiao-Juan Wang, Xin-Xiang Lei*, Residual dipolar couplings in structure determination of natural products, Nat. Prod. Bioprospect., 2018, 8(4): 279-295.
[4] Gaowei Li, Xinxiang Lei*, Structural elucidation of organic molecule from residual dipolar couplings,SCIENTIA SINICA Chimica, 2017, 47(12): 1401-1423.
[5] Gao-Wei Li, Jiang-Ming Cao, Wen Zong, Li Hu, Mao-Lin Hu, Xinxiang Lei*, Han Sun*, Ren Xiang Tan*, Helical Polyisocyanopeptides as lyotropic liquid crystals for measuring residual dipolar couplings, Chem. Eur. J., 2017, 23(32): 7653-7656.
[6] Wen Zong#, Gao-Wei Li#, Jiang-Ming Cao, Xinxiang Lei*, Mao-Lin Hu, Han Sun*, Christian Griesinger, Ren Xiang Tan*, An alignment medium for measuring residual dipolar couplings in pure DMSO: Liquid crystals from graphene oxide grafted with polymer brushes, Angew. Chem. Int. Ed., 2016, 55(11): 3690-3693.
[7] Gaowei Li, Jiangming Cao, Wen Zong, Xinxiang Lei*, Renxiang Tan*, Enantiodiscrimination of carboxylic acids using the diphenylprolinol NMR chiral solvating agents, Org. Chem. Front., 2016, 3(1): 96-102.
[8] Shanshan Liu, Gao-Wei Li, Xiao-Chao Yang, De-Yang Zhang, Min-Can Wang*, Dinuclear zinc complex catalyzed asymmetric methylation and alkynylation of aromatic aldehydes, Org. Biomol. Chem., 2017, 15(34): 7147-7156.
[9] Gary E. Martin, Yizhou Liu, R. Thomas Williamson, Gao-Wei Li, Xinxiang Lei Anisotropic NMR Methods: Orthogonal Verification of Novel and Complex Natural Product Structures, Chapt. 16. The Royal Society of Chemistry, Cambridge, 2021.
2. 专利
[1] 李高伟,王晓娟,张明亮,刘澜涛,刘南南,程怡鹏,李自航,秦宁,周广研,一种聚合物型溶致液晶材料的制备及手性拆分芳基丙酸类抗炎药,中国发明专利,申请号:202010405099.9,公开号:CN111471467A
[2] 李高伟,王晓娟,郝远强,孙秋灵,程怡鹏,一种高选择性检测汞离子荧光探针及其合成方法与应用,中国发明专利,申请号:202010485862.3,公开号:CN111689877A
[3] 赵文献,晁瑞青,李高伟,许凯,王涛,王晓娟,赵瑞娟,刘澜涛,树状高分子负载的联萘酚亚磷酰胺配体、其合成方法及其应用,中国发明专利,专利号:ZL201510032293.6,授权公告日:2016.11.30